- Vaccine delivery
- Drug Delivery
- Diabetes management
- Computational modeling
- Fundamental flow phenomena
- Two-phase flows
- capillary flows
- with particles
- with large biomolecules
- Non-Newtonian fluid mechanics
- Glucose Sensor
- Micro-Capillary Pumped Loop Cooler
Integrated MEMS Systems
have been developed for the delivery of lyopholized or dried drugs.
The drug is delivered in a non-aqueous solution just under the skin
where it is dissolved by the interstitial fluid and absorbed by
the capillary blood vessels. All this is above the nerve endings
so it does not hurt.
The overall goal of this project is to be able to effectively distribute
vaccines in remote areas that do not have sufficient medical care.
On the right is a picture of a microsyringe made by Boris Stoeber.
We have demonstrated that the microneedles do actually deliver drugs
Continuous micro-mixer was our first integrated fluid system. This
device requires only power and a fluid source. Pumping, valving and
mixing are all performed by on-chip MEMS components. The system has
been encased into a custom designed injection molded case. The work
was performed by Ajay Deshmuhk (PhD, M.E., 2002).
The system contains
two positive displacement pumps (each with 2 check valves). The pumps
provide alternating flow in the center channel forming an interface
that gets stretched as the flow evolves downstream. The rapid increase
in interfacial area accelerates mixing as shown in the lower picture.
The fundamental theory behind this approach is that three
degrees of freedom are required for complex flow patterns (see Aref
and Jones papers). MEMS devices are generally planar so in this device
the third degree of freedom is provided by time-dependent flow.
is currently working on a continuous glucose sensor that uses the
micro-needles described above with an integrated flow-through enzymatic
(glucose oxidase) assay. This work, done by Stefan Zimmerman, Boris
Stoeber, and Dorte Fienbork, uses a new approach for "in device" enzyme
patterning that can be done after wafer level fabrication. The
device has four hundred microneedles for the acquisition of interstitial
Pumped Loop for Chip Cooling
circuits today are limited by heat transfer. The schematic above
right shows the third generaion of a micro-CPL cooler which uses
phase change to provide advanced thermal management for multichip
modules. The system shown below right is the device cooling a power
transitor. The system has been demonstrated to remove over 300
Watts per sq. cm. This work was done by Jeff Kirshberg (PhD 2002)
and KIP Pettigrew (MS 2003).