S.A. BERGER RESEARCH

(#'s below refer to papers in Publication List)

1. Flow in Curved Tubes

Over twenty years, I and a colleague (L. Talbot) established at Berkeley one of the most active centers of research on flow in curved tubes and pipes, studies which have application ranging from biofluiddynamics to any situation involving complex piping systems. I directed the analytical and numerical studies. We studied both fully-developed and developing flow, steady and unsteady, including heat transfer effects.

Representative publications:

  1. "Entry Flow in a Curved Pipe," J. Fluid Mech., 67, 1975, 177-196.(#38)
  2. "Flow in Curved Pipes," Ann. Rev. Fluid Mech., Vol. 15, 1983, 461-512.(#63)
  3. "Flow and Heat Transfer in Curved Pipes and Tubes," AIAA 91-0030, 1991. (#88)

(Other publications: #50, 65-66, 69-70, 73-6, 79, 81, 83-5, 87)

2. Vortex Breakdown

Vortex breakdown is the abrupt change in the structure of the concentrated core of a strongly swirling flow, resulting in a recirculation bubble or a spiral about the axis. Various mechanisms have been proposed as responsible for breakdown, but none is yet universally accepted. We were the first to carry out a full numerical simulation of breakdown, solving the full axisymmetric Navier-Stokes equations. This was a seminal paper, leading to more complex simulations, non-axisymmetric and unsteady, as computers became faster and more powerful. My work also addresses the cause of the suddenness of breakdown and its tendency to move upstream, as observed experimentally and in numerical simulations.

A measure of the recognition that I have achieved in this area of research is that I was invited to prepare an article on vortex breakdown for the McGraw-Hill 1997 Yearbook of Science and Technology (#105)

Representative publications:

  1. "Solutions of the Navier-Stokes Equations for Vortex Breakdown," J. of Fluid Mech., 75, 1975, 525-544.(#41)
  2. "Hydrodynamic Stability and Vortex Breakdown," in Mathematical Approaches in Hydrodynamics, Ed. T. Miloh, SIAM, Phila., PA, 1991, pp. 382-403.(#89)

"Vortex Breakdown Incipience: Theoretical Considerations," Physics of Fluids, 7, 1995, 972-982.(#96) (Other publications: #91, 94)

3. Vortex/Free-Surface Interaction

When the vortex wake system produced by a lifting or thrust-producing surface on a ship or submerged vessel interacts with a free surface it produces a very complex disturbance of the free surface, and leaves a characteristic signature on the free surface. I have studied the resulting inviscid interaction and explored the effect of turbulence, in particular how to model the turbulent vortex/free-surface interaction using turbulence models, such as the Reynolds-averaged Navier-Stokes equations.

Representative publications:

  1. "The Interaction Between a Pair of Counter-Rotating Potential Vortices in Vertical Ascent and a Free Surface," in Advances in Fluid Dynamics, W.F. Ballhaus, Jr. and M.Y. Hussaini, Eds., Springer-Verlag, N.Y., 1989, 155-167.(#82)
  2. "The Interaction Between a Counter-Rotating Vortex Pair in Vertical Ascent and a Free Surface," Physics of Fluids, A12, 1989, 1988-2000.(#86)

4. Hydrodynamic Stability

Over my research career I have often returned to one of the ubiquitous subject areas in fluid mechanics: hydrodynamic stability in various contexts. Some of the problems I have looked at, with my students or alone, are:

(a) Towards understanding the separation and containment problem in a gaseous core nuclear rocket, we studied the stability of a two-fluid vortex, in particular the linear hydrodynamic stability of two incompressible, immiscible, viscous fluids of different densities and viscosities occupying separate annular regions of a cylindrical Couette apparatus. While most of our results appeared to be manifestations of the Taylor-Couette instability phenomenon, evidence was presented for the existence of additional "hidden" eigenvalues attributable to the Kelvin-Helmholtz and/or the Yih viscosity-stratification instability phenomenon. (#33)

(b) In #46 we presented an extensive critical review of the literature on the stability and transition of laminar boundary layers, particularly on the strengths and limitations of the well-known empirical e9 transition criterion.

(c) In connection with work for IBM on drop-on-demand ink jet printers, I studied the stability of a thin cylindrical liquid jet, a study initiated by Rayleigh, who is also credited with many of the principal results. All previous investigators treated this problem using a normal-mode type of analysis. As for a number of other stability problems, there were good reasons for reconsidering the jet stability problem as an initial-value problem. I did so, in what turned out to be a substantial analytical analysis. The solution in the limit as time approaches infinity contains all the previously known normal-mode results. The new results, particularly for the sizes of the drops that result from the instability, agree well with experiments. (#64, 68, 77)

(d) In connection with our studies of vortex breakdown, we investigated the stability of the velocity profiles in the flow field behind bubble-type vortex breakdowns, particularly to see whether such flows were themselves unstable, potentially leading to other vortex breakdowns. This required our carrying out a state-of-the-art linear hydrodynamic stability analysis, using techniques for regularizing the solution, and allowing for the presence of non-axisymmetric disturbances. The results confirmed that the flow fields were stable to axisymmetric modes, so a second bubble-type breakdown would not occur, but were unstable to certain nonaxisymmetric modes, which could manifest themselves as spiral or helical breakdowns. These results are consistent with what is known experimentally about single bubble breakdowns, and bubble-followed-by-spiral breakdowns. (#89)

5. Boundary Layer Control

The variation of viscosity with heating for liquids, in contrast with that of gases, presents opportunities for boundary control in water that are very much different than what we know from our more common experience in aerodynamics. The potential to dramatically raise the transition Reynolds number or delay separation for submersible bodies makes the heating of water boundary layers an exciting issue to explore. In our work we first developed approximate methods to calculate the properties of heated water laminar boundary layers (#48, 49), and then carried out an asymptotic analysis of the behavior of these boundary layers near the point of separation and compared the efficacy of heating in delaying separation vs. the use of suction to accomplish the same task (#47)

6. Simulations of Three-Dimensional, Unsteady Flows in Normal and Stenotic Blood Vessels - Applications to MR Angiography

In MRI/A (Magnetic Resonance Imaging/Angiography) of blood flow fluid particles are tagged by complex spatially and temporally varying magnetic fields and then detected at some later time. Construction of the image requires that a model of the flow be used. Traditionally, the model used was a simple one, such as Poiseuille flow. The resulting images of the flow in complex geometries then show areas where it is not clear whether or not the vessels are blocked, and if not, the nature of the flow, laminar or turbulent, in the vessels. Clearly what is called for in constructing these images is a detailed knowledge of the three-dimensional unsteady flows in normal vessels and the greatly more complex flows in vessels with vascular stenoses. My students and I have been successfully numerically simulating these fully three-dimensional unsteady flows in complex arterial geometries. A focus of our work has been on flow in the carotid bifurcation, the carotid arteries being principal arteries supplying blood to the brain, impairment of which is the leading cause of strokes. Our studies have been implemented in the diagnostic studies conducted by our MRI colleagues at the Veterans Administration Hospital/UCSF, principally Dr. Saloner and his associates, our decade-old collaborators in this research. The vessel geometries we study are patient specific and supplied to us by our VA/UCSF colleagues, so our calculations can be directly compared to their MRI, CT, and Doppler diagnostic measurements, as well as to experiments being conducted on the very same geometries at Berkeley by an allied researcher. Our results when incorporated into MRI reconstructions help to resolve many imaging artifacts and to give a more accurate picture of the flow fields in stenotic vessels, crucial to informed clinical diagnosis and planning. Interesting fluid mechanical issues arise in these flows, particularly for severely stenotic vessels. The thin jet that issues from the throat formed at the location of maximum flow narrowing shows signs of instability, as evidenced by unsteadiness of the jet and vortex shedding. Also, although the Reynolds numbers of these flows are not large, of the order of hundreds, there is evidence of disturbed flow, what might be described either as a highly complex vortical flow, or what is sometimes called "chaotic" turbulence (to distinguish it from the more familiar fully-developed high Reynolds number turbulence). Much of our current efforts are directed to numerically capturing this instabiliy, as manifested by unsteadiness and chaotic behavior, by carrying out Reynolds-Averaged Navier-Stokes (RANS) calculations, and Large Eddy (LES) and Direct Numerical Simulations (DNS).

A recent offshoot of my work on the flow in diseased vessels was to begin research on stents, the mechanical scaffolds used to maintain the patency of blood vessels, often following angioplasty, or to reduce aneurysms. In connection with the use of stents placed post-operatively in vessels following angioplasty a major stimulus for calculating the flows in such vessels is a widely held belief that the flow plays a role in restenosis, the re-growth of the vascular wall into the lumen of the vessels, that occurs in roughly 30% of stented vessels (this statement does not hold for the recently introduced drug-coated stents, introduced specifically to overcome this problem).

A measure of the recognition this work has received was the invitation to contribute an article on Flows in Stenotic Vessels for Vol. 32 of Annual Review of Fluid Mechanics, published in January 2000.

Representative publications:

  1. "MR Imaging of Flow through Tortuous Vessels: A Numerical Simulation," Magnetic Resonance in Medicine, 31, 1994, 184-195.(#95)
  2. "Calculation of the Magnetization Distribution for Fluid Flow in Curved Vessels," Magnetic Resonance in Medicine, 35, 1996, 577-584.(#102)
  3. "Numerical Simulation of the Flow in the Carotid Bifurcation," Theoret. Comput. Fluid Dynamics, 10, 1998, 239-248.(#108) (Other publications: #92, 93, 98, 99, 103, 104)
  4. "Influence of Stenosis Morphology on Flow Through Severely Stenotic Vessels: Implications for Plaque Rupture," J. of Biomechanics, 33, 2000, 443-455.(#117)
  5. "Numerical Analysis of Flow Through a Severely Stenotic Carotid Artery Bifurcation," J. Biomech. Eng., 124, 2002, 9-20.(#122)
  6. "A Turbulence Model for Pulsatile Arterial Flows," ASME J. Biomech. Eng. (2004, in press).(#135)
  7. "Numerical Simulation of MR Angiographies of an Anatomically Realistic Stenotic Carotid Bifurcation," Ann. Biomed. Eng. (2004, in press). (#136)
  8. "Research on Fluid-Dynamic Design Criterion of Stent Used for Treatment of Aneurysms by Means of Computational Simulation" (with K. Bando),"Computational Fluid Dynamics Journal, 11, No. 4, 2003, 527-531.(#130)

7. Flow of Sickle-Cell Blood in the Microcirculation

The clinical symptomology of sickle cell disease is primarily a manifestation of abnormal events in the capillaries. In a series of papers I developed a quantitative theoretical model that coupled oxygen transport to the motion of the red blood cells in the capillaries, and that incorporated the most important characteristics of sickle blood. The model predicts conditions conducive to the development of the deleterious effects associated with sickling. This is most likely to occur when there is vasoconstriction of the arterioles. This theory provided the first quantitative explanation of the cause of sickle-cell "crisis". Recently, one of my students (Brian Carlson) has extended the single capillary model to microcirculatory networks. Results for randomly generated distributions of capillaries suggest that capillary blockage is not less than for single capillaries, but even more likely, with significant ramifications for persons with sickle cell disease.

Representative publications:

  1. "The Flow of Sickle-Cell Blood in the Capillaries," Biophysical J., 29, 1980, 591-621. (#53)
  2. "Diffusion and Convection in the Capillaries in Sickle-Cell Disease," Blood Cells, 8, 1982, 153-161. (#60)
  3. "Numerical Simulation of Sickle Cell Blood Flow in the Tranverse Arteriole - Capillary Microvasculature," B.E. Carlson, Ph.D. Thesis, Univ. of Calif., Berkeley, Fall 2001.

(Other publications: #51, 52, 61, 62)

8. Motion of Microorganisms and Rheology of Biological Fluids

Over many years we developed at Berkeley one of the leading centers for research on the motion of microorganisms, particularly self-propelling flagellated organisms such as spermatozoa. Our studies concentrated on the analysis of these when the flagella are of finite length and the waves along the flagella are of finite amplitude. These analyses, which were both analytical and numerical, provided more accurate simulations of the actual motion of such microorganisms. These studies led to investigations of the effects on these motions of nearby solid boundaries, and non-Newtonian behavior of the media in which they were propelling themselves.

Representative publications:

  1. "The Propulsion by Large Amplitude Waves of Uniflagellar Microorganisms of Finite Length," J. Fluid Mech., 97, 1980, 591-621.(#54)
  2. "Flagellar Propulsion of Human Sperm in Cervical Mucus," Biorheology, 17,1980, 169-175.(#55)
  3. "Non-Linear Viscoelastic Properties of Cervical Mucus, Biorheology, 17, 1980, 465-478.(#57) (Other publications: #42, 43, 56, 67, 72)

9. Wake Flows

My early research was on wake flows, both the near wake and the far wake behind bluff and thin bodies, generally for laminar flow conditions, for both small and large Reynolds numbers. I wrote a monograph providing a comprehensive, critical review and survey of the research in this field.

Representative publications:

  1. "The Base Flow and Near Wake Problem at Very Low Reynolds Numbers," Parts I and II, J. Fluid Mech., 23, 1965, 417-438 and 439-458.(#13, 14)
  2. "The Incompressible Laminar Axisymmetric Near Wake Behind a Very Slender Cylinder in Axial Flow," AIAA J., 3, 1965, 1806-1812.(#12)
  3. "A Theoretical and Experimental Investigation of the Compressible Laminar Wake Behind a Long Slender Cylinder," AIAA J., 6, 1968, 1528-34.(#25)
  4. LAMINAR WAKES, Elsevier, New York, 1971. (#34)

(Other publications: #15, 19, 20, 21, 23, 26, 29, 31)

10. Explosions

Beginning with my doctoral thesis and continuing for some years, I studied the fluid dynamics of explosions, both analytically and numerically. The earlier work was on inviscid finite-charge blast waves in water where the flow field behind the leading shock is complicated by the presence of a secondary shock which initially propagates outward, then implodes towards the center, and reflects. Subsequent work concentrated on explosions in heat conducting and viscous gases, including the effects of radiation.

Representative publications:

  1. "Boundary Layer Theory for Blast Waves," J. Fluid Mech., 71, 1975, 65-88.(#40)
  2. "Effects of Internal Heat Transfer on the Structure of Self-Similar Blast Waves," J. Fluid Mech., 117, 1982, 473-491.(#59)

(Other publications: #1, 2, 3, 5, 39)

11. Magnetohydrodynamics and Flow of Ionized Gases

The MHD equations governing the flow of a conducting gas interacting with a magnetic field are nonlinear and so exact solutions are rare. When the gas is infinitely conducting and flows in such a way that the velocity and magnetic fields are aligned, the governing equations may formally be reduced to those of ordinary gas dynamics. If one restricts attention to plane flows then the hodograph technique may be employed, and the equations solved exactly. The problem remains of satisfying the boundary conditions. In a series of papers (#10, 16-18) I solved this problem exactly for an important and realistic geometry, the flow of a jet of gas out of a slit in a rectangular channel. The method used is a modification of the method of Chaplygin for nonconducting gas jets. Like exact solutions in non-MHD flows, such exact solutions are important in themselves, exhibiting the full interplay of nonlinear effects, and as generic problems against which to evaluate approximate and numerical solutions. [These papers appeared only as RAND Research Memoranda because they are widely distributed to depository libraries around the world and therefore considered by many technical journals as archival publications and thus not "re-publishable" in such journals.]

In an important contribution to hydromagnetics (#30), we analyzed the structure of a hydromagnetic ionizing shock wave and showed how an analysis of the structure resolves a well-known indeterminacy in the solution of the shock jump conditions arising from the inability to fix the upstream electric field for ionizing shock waves.

12. The Application of Fluid Mechanics to Materials Processing

Materials processing often involves very complex fluid mechanical phenomena, long recognized by material scientists and acted upon accordingly. It is more recently that fluid mechanicians have recognized this, and it has not escaped the attention of industry and government agencies that interaction between these two groups could lead to dramatic improvements in materials quality and cost, lead to the development of new processes, improvement of current processes, etc. (#78). In particular, I looked at the problem of melt spinning in the aluminum industry, as part of my long association with Alcoa as a consultant and grant recipient. A model which allowed an overall evaluation and optimization of the planar flow casting melt-spinning process was presented in #80. (Many of my contributions to this process as used by industrial leaders such as Alcoa were in the form of informal and formal technical discussions with the engineers supervising the operations.)

(A measure of the recognition I received for work in this area was the invitation to organize and chair an NSF Workshop on the Application of Fluid Mechanics to Materials Processing. The Workshop was held at NSF Headquarters in Washington, D.C. in March, 1988, and included some of the most respected figures in fluid mechanics and materials science.)

13. Miscellaneous Research:

(a) Mathematical Ship Lofting
Our work was the first major attack on the problem of how to eliminate the full or tenth-scale manual loft to draw ships' lines by using instead sophisticated mathematical and computational techniques. We came up with an innovative linear programming approach to fit two-dimensional splines to waterlines and three- dimensional splines to ships' surfaces. Using linear programming allows one to impose requisite smoothness and other, overall constraints on the fitted curves and surfaces. Our work (#6, 22) was seminal, followed often in later years by less powerful and less innovative alternative approaches.

(b) Unsteady Compressible Boundary Layers
We addressed and treated a few important and interesting topics and problems in compressible boundary layers, one a general procedure for obtaining approximate unsteady one-dimensional solutions based on expansions in Mach number (#24), and the other an analysis of compressibility effects in the boundary layer ahead of an accelerating flame (#28)

(c) Analytical Studies of Sails
In a series of papers (#27, 32), one of which appeared in the Proceedings of the Royal Society, communicated by Sir James Lighthill, we treated for the first time analytically the interaction of a mainsail and a jib, to investigate how and when the jib interacts with the flow about the mainsail, namely whether the main effect of the jib is to create a "slot" between it and the mainsail, or to act as a second, albeit smaller, sail. Our analysis was a complex study of two flexible, thin, lifting surfaces, assumed to be two-dimensional, leading to coupled linear integral equations. The solution of these equations is exceedingly complex. The resulting solution shows that both of these mechanisms can occur, depending on the separation distance and the angle between the jib and the mainsail.


BOOKS:

1. LAMINAR WAKES, S. A. Berger, Elsevier. New York, 1971. This was a critical treatise covering work on incompressible and compressible, subsonic and supersonic wakes. Wakes flow are a classical topic in fluid dynamics. In the nineteen fifties and sixties, because of military considerations, there was an enormous effort in investigating complex wake flows behind slender and bluff bodies, compressible in general and, particularly, high-speed flows. This book was the first and most comprehensive treatise covering the classical work and the modern investigations.


2. INTRODUCTION TO BIOENGINEERING, S. A. Berger, W. Goldsmith, E. R. Lewis, Editors, Oxford University Press, Oxford, 1996. This is a first-year graduate or senior-level undergraduate text on bioengineering. Unlike other multi-authored books, preparing this book was far different than putting together a set of chapters. It required a great deal of oversight and involvement of the editors. The major contributions were by myself and Goldsmith (E.R. Lewis took early retirement after agreeing to be one of the editors), myself as the principal person in synthesizing and putting together the book, Goldsmith in preparing the first and largest chapter of the book, on biomechanics. (I also wrote one of the longest chapters, on physiological fluid mechanics.)


REVIEW ARTICLES, CONTRIBUTIONS TO HANDBOOKS, YEARBOOKS, ETC.:

  1. "Fluid-Mechanical Aspects of the Human Circulation", (with L. Talbot), American Scientist, Vol. 62, No. 6, Nov.-Dec. 1974, pp. 671-682. (Also reprinted in part in Non-Invasive Diagnostics Newsletter, Vol. 3, No. 4, 1975.)
  2. "Flow in Curved Pipes", (with L. Talbot, L.-S. Yao), in Annual Review of Fluid Mechanics, Vol. 15, 1983, pp. 461-512.
  3. "Flows in Stenotic Vessels", (with L.-D. Jou), in Annual Review of Fluid Mechanics, Vol. 32, 2000, pp. 347-382.
  4. "Vortex", McGraw-Hill 1997 Yearbook of Science and Technology, 1996, pp. 485-487.
  5. "Fluid Mechanics", in CRC Handbook of Mechanical Engineering, F. Kreith, Ed., 1st ed., CRC Press, Boca Raton, Fl., 1998, pp. 3.2-3.27. Also, 2nd ed., F. Kreith & D. Y. Goswami, Eds., 2004, pp. 3.2-3.25.
  6. "Fluid Mechanics", in CRC Handbook of Thermal Engineering, F. Kreith, Ed., CRC Press, Boca Raton, FL., 1999, pp. 2.1-2.27.


Latest update: November 19, 2004
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