ME C117 - Structural Aspects of Biomaterials [3 units]
CATALOG DESCRIPTION
This course covers the mechanical and structural aspects of biological tissues and their replacements. Tissue structure and mechanical function are addressed. Natural and synthetic load-bearing biomaterials for clinical and medical applications are reviewed. Biocompatibility of biomaterials and host response to structural implants are examined. Quantitative treatment of biomechanical issues and constitutive relationships of tissues and biomaterials are covered. Material selection for load-bearing applications including reconstructive surgery, orthopedics, dentistry, and cardiology. Mechanical design for longevity including topics of fatigue, wear, and fracture. Use of bioresorbable implants and hybrid materials. Directions in tissue engineering. Also listed as Bioengineering C117.
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COURSE PREREQUISITES
Biology 1A, Engineering 45, and Civil Engineering 130.
TEXTBOOK(S) AND/OR OTHER REQUIRED MATERIAL
COURSE OBJECTIVES
The objective is to provide a systematic coverage of
biomechanical properties as they relate to
tissues, biomaterials, and devices. these properties
include isotropy/anisotropy, stiffness, bending stresses,
contact stresses, multiaxial loading, plasticity,
fatigue, fracture, wear, corrosion, and mechanical design issues.
Case studies in orthopedics, dental, cardiovascular and soft
tissue repair are presented.
DESIRED COURSE OUTCOMES
Students should have an undestanding of design and
structural issues related to medical devices used to
restore function to load bearing tissues.
Students will also have knowledge of FDA regulatory issues,
biocompatibility and sterilization technology
for devices and biological materials.
TOPICS COVERED
Overview of biomaterials.
Review of cell and tissues, structure-function relationships.
Biocompatibility, Foreign Body Response, and Wound Healing.
Medical Devices and FDA Regulatory Issues.
Synthetic biomaterials and sterilization technology.
Review of important mechanical properties.
Biomechanical design issues: plastic deformation, fatigue, fracture, wear, corrosion.
ORTHOPEDIC TISSUES AND BIOMATERIALS: Structure and function of
orthopedic tissues. Mechanisms for damage and disease. Clinical treatments.
CARDIOVASCULAR TISSUES AND BIOMATERIALS: Structure and
function of vascular tissue. Etiology of cardiovascular disease.
Clinical treatments. Vascular devices.
SOFT TISSUE RECONSTRUCTION: Structural Properties, wound healing, stability,
biofixation.
DENTAL TISSUES AND BIOMATERIALS: Structure and function of dental tissues.
Progression of disease. Clinical treatments. Dental materials/restorative materials
CLASS/LABORATORY SCHEDULE
Three hours of lecture and one hour of discussion per week.
CONTRIBUTION OF THE COURSE TO MEETING THE PROFESSIONAL COMPONENT
Teamwork: Work in teams on a semester long design project.
Communication Skills: Technical write-up and presentation at the end of the semester.
Teaching component to middle school children.
RELATIONSHIP OF THE COURSE TO
ABET PROGRAM OUTCOMES
An ability to design a system, component, or process to
meet desired needs within realistic constraints such
as economic, environmental, social, political, ethical,
health and safety, manufacturability, and sustainability.
An understanding of professional and ethical responsibility.
An ability to communicate effectively.
The broad education necessary to understand the impact
of engineering solutions in a global, economic, environmental,
and societal context.
A recognition of the need for, and an ability to engage in life-long learning.
An ability to use the techniques, skills, and modern engineering
tools necessary for engineering practice.
ASSESSMENT OF STUDENT PROGRESS TOWARD COURSE OBJECTIVES
Continual surveys administered.
PERSON(S) WHO PREPARED THIS DESCRIPTION:
Lisa Pruitt
